Magnesium Glycinate Caps *NEW ITEM* (Premier Magnesium Glycinate Caps)
Magnesium Glycinate Caps *NEW ITEM* (Premier Magnesium Glycinate Caps)
Magnesium Glycinate Caps *NEW ITEM* (Premier Magnesium Glycinate Caps)
Premier Research Labs (PRL)

Magnesium Glycinate Caps *NEW ITEM* (Premier Magnesium Glycinate Caps)

Premier Magnesium Glycinate Caps


  • Facilitates relaxation and stress reduction.*
  • Activates critical nerve impulses to support brain and nervous system function.*
  • Promotes muscle relaxation and bone health.*
  • Supports cardiovascular function and vascular integrity.*
  • Assists with relaxation, sleep quality, and duration for comprehensive restoration.*
  • Gentle, effective, and highly absorbable magnesium amino acid chelate.*

Enhance relaxation and overall vitality with Premier Magnesium Glycinate Caps!

Magnesium is not just a mineral; it's a versatile ally that supports various bodily functions, ensuring your overall health and well-being are supported. From facilitating relaxation, easing muscle tension, promoting cardiovascular health, and enhancing sleep quality, Magnesium boasts many essential health benefits for supporting holistic health goals. Its comprehensive wellness benefits are a testament to its effectiveness and reliability.

However, Magnesium deficiency affects over 75% of the population due to poor diet, GI or kidney conditions, age, and stress. Certain medications worsen deficiency by increasing urinary magnesium loss. But you can break this cycle with Premier Magnesium Glycinate Caps! Our formulation, meticulously crafted with Premier Quality ingredients and backed by rigorous scientific research, ensures maximum bioavailability for accessing Magnesium’s comprehensive health benefits, giving you the confidence that you're choosing a trusted and effective solution.

This heightened absorption is attributed to the glycine molecule, which acts as a chelating agent, binding to the Magnesium and facilitating its passage through the intestinal wall. As a result, more Magnesium reaches the systemic circulation, maximizing its effectiveness in supporting various bodily functions.

Formulated with sensitive digestion in mind, our vegan capsules combine elemental Magnesium and the calming properties of glycine, the amino acid component of magnesium glycinate, which further contributes to its therapeutic effects. Glycine promotes relaxation and helps alleviate stress, making Premier Magnesium Glycinate Caps an excellent choice to address magnesium deficiency and optimize overall mental and physical well-being.

Suggested Use: For optimal absorption, take orally with water, preferably with meals.

Contraindications & Cautions: Excessive intake of magnesium glycinate can cause GI issues. Use caution in Individuals with pre-existing medical conditions, like kidney conditions, and those taking essential medications.


Explore the critical role of magnesium in clinical practice and uncover the transformative impact it can have on patient well-being. Magnesium is involved in more than 300 biochemical reactions and numerous physiological processes throughout the body, including nerve function, muscle contraction, and regulation of blood pressure and glucose levels. As such, inadequate magnesium intake or absorption can impact various systems critical to maintaining peak health and wellness.1,2

Several studies have indicated the benefits associated with adequate magnesium status and mental health. 2 Magnesium plays a role in neurotransmitter function and regulation of stress responses, suggesting that deficient magnesium levels may influence mental health outcomes. 

Premier Magnesium Glycinate Caps offer an invaluable tool to stop the vicious cycle of magnesium deficiency, providing Premier Quality support to fill dietary gaps in magnesium intake, improving absorption and assimilation of this essential nutrient. Utilize Premier Magnesium Glycinate Caps to:


According to the medical literature, Americans are currently experiencing two simultaneous phenomena: (i) a “neglected epidemic of chronic disease” and (ii) a widespread deficiency of specific essential nutrients.2-5 Magnesium is one of the most essential minerals in our bodies, after calcium, sodium, and potassium. It's found mainly inside the mitochondria of our cells, where it plays a pivotal role in the synthesis of ATP (adenosine triphosphate).2

Emerging research suggests that magnesium deficiency may contribute to the development and exacerbation of chronic diseases, including mental health disorders. It is estimated that between 56% - 68% of Americans do not obtain, nor absorb enough magnesium in their diet daily to meet the recommended daily allowance (RDA) of 300-400 mg.1,2,6

Magnesium deficiency can present with various symptoms, including muscle cramps, fatigue, nausea, mood changes, sleep disturbances, headaches, irregular heartbeat, and tingling sensations. As magnesium plays a crucial role in muscle function, energy production, mood regulation, and nerve transmission, low levels can impact multiple bodily systems.2,6

Magnesium deficiency can arise from a combination of factors, including soil depletion from industrial farming practices and the use of mineral-chelating glyphosate (aka ‘Round-Up” pesticide), food processing and cooking methods, existing vitamin D deficiency, medication use, and lifestyle factors.7

Magnesium is not only difficult to absorb but also water-soluble.  Individuals experiencing blood sugar dysregulation, alcoholism, cigarette smoking, or intake of medications like Proton Pump Inhibitors, certain antibiotics, and diuretics result in a detrimental loss of excessive amounts of this modulating mineral.1,2,6 High-dose calcium and vitamin D supplementation is associated with urinary loss of magnesium. Without adequate magnesium, the balance of these minerals in the body can become disrupted, negatively impacting bone health.2 It is essential to consider these factors when assessing magnesium status and implementing strategies to address the deficiency.


Magnesium glycinate is a popular magnesium supplement known for its high bioavailability and minimal digestive discomfort. The specific structure of magnesium glycinate, which combines magnesium with the amino acid glycine, enhances its absorption and utilization in the body. This improved absorption helps ensure that a more significant amount of magnesium reaches the bloodstream, allowing the full range of magnesium benefits to be realized.6

Additionally, magnesium glycinate's gentle nature typically results in fewer digestive issues compared to other forms of magnesium supplements, making it well-suited for individuals with sensitive stomachs or gastrointestinal concerns. Magnesium glycinate offers a practical and well-tolerated option for achieving optimal magnesium levels and supporting overall health.


Magnesium glycinate offers a unique combination of enhanced absorption, gentle nature, relaxation benefits, improved sleep quality, and support for muscle health and recovery, making it an excellent choice for individuals seeking to optimize their magnesium levels and support overall health and well-being.

Research indicates that magnesium glycinate supplements support numerous body systems, especially as we grow older, and may benefit those who frequently experience migraines as well as premenstrual syndrome (PMS) resulting from hormone imbalance and/or chronic stress.2

Heart health.  Magnesium supports healthy blood pressure and may contribute to preventing cardiovascular disease. Low magnesium levels contribute to vascular calcification, increased triglycerides, reduced HDL cholesterol transport, and other changes in blood vessel structure and lipid exchange.2,8 

Musculoskeletal and Nervous System Health. Magnesium helps regulate muscle contractions and nerve impulses, contributing to relaxation, reducing muscle cramps, PMS, and migraines, and supporting healthy sleep.9-12

Mental and Neurological Health. Magnesium deficiency is prevalent among children with attention deficit hyperactivity disorder (ADHD), with supplementation demonstrating significant improvements in attention and hyperactivity indices. 13,14 Additionally, emerging evidence suggests that low magnesium levels, in addition to high aluminum levels, are implicated in Parkinson’s disease.15  Additionally, magnesium supplementation has been investigated as a potential adjunctive therapy for schizophrenia, with some studies suggesting beneficial effects on symptom severity and treatment outcomes, prompting investigation into magnesium supplementation as an adjuvant therapy.16

Bone Health. Magnesium supplementation has been associated with higher bone mineral density in elderly white men and women. It has been shown to suppress bone turnover in postmenopausal women and young adult males. 17-19 However, both excessively high and low magnesium levels appear to be detrimental to bone health. 20 

Metabolic health. Higher dietary magnesium intake is associated with a 47% lower incidence of diabetes, suggesting its importance in preventing metabolic syndrome, where magnesium levels tend to be lower.21,22

Maternal health. Based on preliminary evidence, magnesium supplementation during pregnancy may support maternal health by potentially reducing the risk of adverse pregnancy outcomes and promoting the infant's long-term health.23

Stress Management. Stress, whether physical stress (including heat, cold, exertion, trauma, or surgery), emotional stress (including excitement, worry, and melancholy mood), or shortness of breath such as that found in asthma, increases the need for supplemental magnesium.24


Magnesium can be difficult for the body to absorb. Its bioavailability varies depending on its chemical form. Magnesium glycinate boasts higher bioavailability than Magnesium citrate, allowing for a significant portion of the magnesium to be absorbed into the bloodstream after ingestion.1 This heightened absorption is attributed to the glycine molecule, which acts as a chelating agent, binding to magnesium and facilitating its passage through the intestinal wall. As a result, more magnesium reaches systemic circulation, maximizing its effectiveness in supporting various bodily functions.


While magnesium glycinate is generally well-tolerated and associated with minimal side effects, it’s important to be aware of potential adverse effects, drug-nutrient interactions, and dosing concerns:1,2

Gastrointestinal Effects: Although magnesium glycinate is considered gentle on the stomach compared to other forms of magnesium supplements, some individuals may still experience mild gastrointestinal discomfort such as diarrhea, bloating, or abdominal cramping, particularly when taking high doses. Adjusting the dosage or taking the supplement with food may help alleviate these symptoms.

Drug Interactions: Magnesium supplements, including magnesium glycinate, can interact with certain medications. For example, magnesium may interfere with the absorption of certain antibiotics, bisphosphonates (used to treat osteoporosis), and drugs used to manage certain heart conditions. Additionally, magnesium supplements may enhance the effects of muscle relaxants and medications that lower blood pressure. 

Dosing Concerns: The recommended dosage of magnesium glycinate can vary depending on individual factors such as age, sex, health status, and dietary magnesium intake. Generally, starting with a lower dose and gradually increasing as needed while monitoring for any adverse effects is advisable. The Recommended Dietary Allowance (RDA) for magnesium for adults is typically around 300-400 mg per day, but individual requirements may vary. Excessive intake of magnesium supplements can lead to diarrhea, nausea, and other adverse effects, so it’s essential to stay within the recommended dosage without medical supervision.

Individual Sensitivities: While magnesium glycinate is well-tolerated by most individuals, some may be sensitive to magnesium or glycine. You should avoid magnesium glycinate supplementation if you have a known allergy or sensitivity to either of these substances.
Magnesium glycinate is considered a safe and effective supplement for many individuals. Still, it’s essential to be mindful of potential side effects, drug interactions, and dosing considerations, especially if there are underlying health conditions.  


While magnesium glycinate supplementation is likely needed for most American adults, it is essential to know that the absorption of magnesium glycinate can be influenced by factors such as the timing of dosing and whether it's taken with or without food.2

Timing of Dosing: While there isn't a specific time of day that guarantees optimal absorption of magnesium glycinate, some people find it beneficial to take it at certain times based on personal preference or health goals. For example, taking magnesium glycinate before bed may help promote relaxation and improve sleep quality due to its calming effects. Others prefer taking it in the morning to support energy levels and overall well-being. Ultimately, the best time to take magnesium glycinate depends on individual preferences and lifestyle factors.

With or Without Food: Magnesium absorption can be influenced by the presence of food in the stomach. Taking magnesium supplements with food may enhance absorption and reduce the risk of gastrointestinal discomfort in some individuals. However, magnesium glycinate is typically well-tolerated and may be taken with or without food based on personal preference. If someone experiences digestive issues with magnesium supplements, taking them with food may help alleviate any discomfort.



  1. Magnesium. Fact Sheet for Health Professionals. National Institute of Health Office of Dietary Supplement
  2. Schwalfenberg, Gerry K, et al.  “The Importance of Magnesium in Clinical Healthcare.” Scientifica vol. 2017 (2017): 4179326.

  3. Horton R. “The neglected epidemic of chronic disease.” The Lancet. 2005;366(9496, article 1514)  

  4. Genuis S. J. “What's out there making us sick?” Journal of Environmental and Public Health. 2012;2012:10. 

  5. Genuis S. J. “Nutritional transition: a determinant of global health.” Journal of Epidemiology and Community Health. 2005;59(8):615–617.  

  6. Razzaque MS. “Magnesium: Are We Consuming Enough?” Nutrients. 2018;10(12):1863. Published 2018 Dec 2.    

  7. Samsel A, Seneff S. "Glyphosate, pathways to modern diseases III: Manganese, neurological diseases, and associated pathologies.” Surg Neurol Int. 2015;6:45. Published 2015 Mar 24.  

  8. Rayssiguier Y. “Role of magnesium and potassium in the pathogenesis of arteriosclerosis.” Magnesium. 1984;3(4-6):226-238.  

  9. Luo L, et al. “Interventions for leg cramps in pregnancy.” Cochrane Database Syst Rev. 2020;12(12):CD010655. Published 2020 Dec 4. 

  10. Abbasi B, et al. “The effect of magnesium supplementation on primary insomnia in elderly: A double-blind placebo-controlled clinical trial.” J Res Med Sci. 2012;17(12):1161-1169.  

  11. Peikert A, et al. “Prophylaxis of migraine with oral magnesium: results from a prospective, multi-center, placebo-controlled and double-blind randomized study.” Cephalalgia. 1996;16(4):257-263.  

  12. Facchinetti, F, et al. “Oral magnesium successfully relieves premenstrual mood changes.” Obstetrics and Gynecology, vol. 78, no. 2, pp. 177–181, 1991.  

  13. Mousain-Bosc M, et al. “Improvement of neurobehavioral disorders in children supplemented with magnesium-vitamin B6.I. Attention deficit hyperactivity disorders.” Magnes Res. 2006;19(1):46-52.

  14. Starobrat-Hermelin B, et al. “The effects of magnesium physiological supplementation on hyperactivity in children with attention deficit hyperactivity disorder (ADHD). Positive response to magnesium oral loading test.” Magnes Res. 1997;10(2):149-156.  

  15. Yasui M, et al. “Calcium, magnesium and aluminum concentrations in Parkinson's disease.” Neurotoxicology. 1992;13(3):593-600.  

  16. Ordak M, et al. “Magnesium in schizophrenia.” Pharmacol Rep. 2017;69(5):929-934.  

  17. Ryder KM, et al. “Magnesium intake from food and supplements is associated with bone mineral density in healthy older white subjects.” J Am Geriatr Soc. 2005;53(11):1875-1880.  

  18. Aydin H, et al. “Short-term oral magnesium supplementation suppresses bone turnover in postmenopausal osteoporotic women.” Biol Trace Elem Res. 2010;133(2):136-143.  

  19. Dimai HP, et al. “Daily oral magnesium supplementation suppresses bone turnover in young adult males.” J Clin Endocrinol Metab. 1998;83(8):2742-2748.  

  20. Castiglioni S, et al. “Magnesium and osteoporosis: current state of knowledge and future research directions”. Nutrients. 2013;5(8):3022-3033. Published 2013 Jul 31.  

  21. Ju SY, et al. “Dietary magnesium intake and metabolic syndrome in the adult population: dose-response meta-analysis and meta-regression.” Nutrients. 2014;6(12):6005-6019. Published 2014 Dec 22.  

  22. Kim DJ, et al. “Magnesium intake in relation to systemic inflammation, insulin resistance, and the incidence of diabetes.” Diabetes Care. 2010;33(12):2604-2610.  

  23. Makrides M, et al. “Magnesium supplementation in pregnancy.” Cochrane Database Syst Rev. 2014;2014(4):CD000937. Published 2014 Apr 3.  

  24. Seelig, M. S. (1994) “Consequences of magnesium deficiency on the enhancement of stress reactions; preventive and therapeutic implications (a review).”, Journal of the American College of Nutrition, 13(5), pp. 429–446  

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