Mg-Zyme (Magnesium Chelates) 100 Caps

Mg-Zyme (Magnesium Chelates) from Biotics Research Corp.

MG-Zyme Magnesium (as magnesium aspartate, magnesium gluconate, and magnesium glycinate)

As an essential to all living cells, magnesium (Mg) serves as a key element in cellular metabolism and participates as a required co-factor or an active component in an astounding number of metabolic reactions – over 300 in fact.

Although an abundant mineral in living systems, as well as in the food chain, intake is often insufficient to meet physiological needs, as the American diet is laden with highly processed foods, often devoid of magnesium.1 Compounding this is the fact that bodily absorption of Magnesium is not efficient, with estimates indicating that of the daily dietary Magnesium intake, only 30-70% is absorbed.2

Low levels of Magnesium are often correlated with an imbalance in other minerals, including calcium, sodium, and potassium, which in turn may have an effect on cardiovascular health. In fact, magnesium deficiency has been said to result in an increased concentration of intracellular cardiac myocytes, which in turn leads to the formation of inflammatory cytokines and reactive oxygen species, resulting in the development of cardiovascular complications.10

Magnesium may be more vital than previously recognized, as current literature indicates that “new and old findings appear to delineate an increasingly complex and important role for magnesium in many cellular functions.”13

Mg is also necessary for the activity of vitamin D, as the active form of vitamin D is not as active in promoting the intestinal absorption of calcium uptake in the absence of Magnesium.2

Thus, due to its importance in many bodily systems, and the fact that dietary intake is usually inadequate to meet even basic bodily requirements, supplemental Magnesium is a judicious choice for healthcare practitioners. Magnesium can safely be incorporated into all regimens, as a means to both address deficiency and to promote wellbeing. In addition, the forms of Magnesium supplied in Mg-Zyme™ are recognized as having excellent bioavailability and absorption.

Magnesium and GABA Receptors in the Brain

Magnesium plays an important role in a multitude of biochemical reactions in the body, including the brain. Neurological functions of magnesium include cellular energy product, regulating neurotransmitters such as serotonin, dopamine and gamma-Aminobutyric acid (GABA), regulating ion gradients, and neuronal excitability.

Dysregulation of these systems plays an important role in the etiology of both depression and anxiety.

Magnesium has been shown to modulate GABA activity in the brain. Magnesium ions can occupy GABA receptors acting as GABA receptor agonists to help facilitate GABA neurotransmission. GABA is an inhibitory neurotransmitter in the brain that plays a role in motor control, vision, and anxiety.

Recommendation: 1 capsule daily or as directed by your health care professional.

References: 1. Marier JR. Magnesium Content of the Food Supply in the Modern-Day World.  Magnesium 1986 5: 1-8. (Presented at the International Symposium on ‘  Magnesium and Its Relationship to Cardiovascular, Renal, and Metabolic   Disorders’, Los Angeles, Feb. 12 1985.) 2. Berdanier C. Advanced Nutrition Micronutrients.1998. CRC Press. 3. Altura BM, Altura BT. Role of magnesium in pathophysiological processes and  the clinical utility of magnesium ion selective electrodes. Scand J Clin Lab  Invest Suppl. 1996;224:211-34. 4. Rubin H. 1975. Central role for magnesium in coordinate control of metabolism  and growth in animal cells. Proc Natl Acad Sci USA. 72:3551–3555. 5. Switzer RL. 1971. Regulation and mechanism of phosphoribosylpyrophos-  phate synthetase. III. Kinetic studies of the reaction mechanism.   J Biol Chem. 246:2447–2458. 6. Cowan, J. A. The Biological Chemistry of Magnesium.1995 VCH, New York. 7. J. Durlach. Les contrôles neuro-hormonaux du métabolisme du magnésium et   leurs conséquences liniques. Rev. Franç. Endocrinol. Clin., 21, 6, 507-524,   1980. 8. Rink, E.B.: Magnesium deficiency etiology and clinical spectrum.   Acta Med Scand. 1983 Suppl. 647:125-137. 9. Whang, R. Magnesium deficiency: causes and clinical implications.   Drugs 1984 28 (suppl. 1):143-150. 10. Kurabayashi M. Role of magnesium in cardiac metabolism.   Clin Calcium. 2005 Nov;15 (11):77-83. 11. Agus MS, Agus ZS. Cardiovascular actions of magnesium.   Crit Care Clin. 2001 Jan;17 (1):175-86. 12. Rodríguez-Morán M, Guerrero-Romero F. Serum magnesium and C-reactive   protein levels. Arch Dis Child. 2008 Aug;93(8):676-80. Epub 2007 Jul 19. 13. Wolf FI, Trapani V. Cell (patho)physiology of magnesium.   Clin Sci (Lond). 2008 Jan;114 (1):27-35.