HistoPlex-AB from Biotics Research Corp.
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HistoPlex-AB for airborne allergies and immune support
Botanical Support of the Immune System
Supplies a proprietary blend of herbal extracts shown to possess immunomodulating Nutritional support for those with allergies.
This product is gluten and dairy free!
RECOMMENDATION: Two (2) capsules two (2) times each day as a dietary supplement or as otherwise directed by a healthcare professional.
The Immune System:
The immune system normally discriminates between “self” and “non-self” foreign substances. Thus, it represents an elaborate, finely tuned defense system to destroy microorganisms, cancer cells, or other invasive materials. However, an imbalanced immune system can attack the body’s own tissues (auto-immune conditions) and lead to cumulative oxidative stress.
The immune system consists of two branches, cellular immunity and humoral immunity. The first depends upon the active participation of multiple cell types, including a variety of phagocytic cells, to engulf invaders. Lymphocytes include highly specialized T cells, which proliferate and differentiate in the thymus gland. In a typical scenario, macrophages process ingested antigens and display recognition fragments on their surfaces.
T helper cells acting as generals, read these antigens and in turn stimulate the production of T killer cells via lymphokines such as IL-2 and gamma interferon. Mast cells are a type of T cell embedded in tissues to fight localized infection. When they contact foreign materials, mast cells destroy them. In the process, they release histamine and other agents that cause edema, increase blood vessel permeability and recruit neutrophils to the site of inflammation.
Allergies: An allergic response involves both cellular and humoral mechanisms. In contrast, other types of sensitivities to foods, such as lactose intolerance or sulfite sensitivity, do not employ the immune system. Allergic responses can be generally classified as immediate or delayed hypersensitivities. Immediate hypersensitivity represents a rapid over-reaction of the immune system, often within minutes after exposure to the problem antigen. Particularly mast cells release histamine, leukotrienes and other stimuli that evoke swelling, hives, itchiness, copious mucus secretion and muscle spasm of the GI tract and bronchioles. The reaction is mediated by IgE antibodies.
Faulty digestion and increased gut permeability are often a root cause of multiple food allergies, because food allergens that are normally excluded, cross the intestinal barrier and enter the bloodstream. The resulting immune complexes, if not cleared rapidly, can lodge in various organs and tissues where they can trigger inflammatory conditions.
Food allergies have been linked to a range of auto immune conditions, rheumatoid arthritis, for example.1 Detecting food allergies can be perplexing. The delay between ingesting a specific food and the development of sometimes vague symptoms often masks food allergy reactions. The most frequent symptom is fatigue. Other symptoms include delayed hypersensitivity, irritability, achy joints, blood sugar dysregulation, PMS-like symptoms, puffy eyes with dark circles and postnasal drip.
Food allergies can cause asthma when they affect the respiratory tract; headache and insomnia when they affect the nervous system; and indigestion, irritable colon, constipation or diarrhea when they affect the GI tract.
Caution: Not recommended for pregnant or lactating women, children under 12 years of age, those with an autoimmune disease or having a significantly compromised immune system, or those with an acute infection. Nutritional support for those with allergies \nProduct #6340 Technical Support \nThe Immune System The immune system normally discriminates between “self” and “non-self” foreign substances. Thus, it represents an elaborate, finely tuned defense system to destroy microorganisms, cancer cells, or other invasive materials. However, an imbalanced immune system can attack the body’s own tissues (auto-immune conditions) and lead to cumulative oxidative stress. \nThe immune system consists of two branches, cellular immunity and humoral immunity. The first depends upon the active participation of multiple cell types, including a variety of phagocytic cells, to engulf invaders. Lymphocytes include highly specialized T cells, which proliferate and differentiate in the thymus gland. In a typical scenario, macrophages process ingested antigens and display recognition fragments on their surfaces. T helper cells acting as generals, read these antigens and in turn stimulate the production of T killer cells via lymphokines such as IL-2 and gamma interferon. Mast cells are a type of T cell embedded in tissues to fight localized infection. When they contact foreign materials, mast cells destroy them. In the process, they release histamine and other agents that cause edema, increase blood vessel permeability and recruit neutrophils to the site of inflammation. \nHumoral immunity pertains to proteins of the blood and lymph. This aspect of the immune system relies on B cells which mature to plasma cells that secrete specific antibodies and complement proteins to fight infections. Complement also triggers localized inflammation. T helper cells regulate the production and maturation of B cells through lymphokines. T suppressor cells gear down the immune response and thus are critical in allergy attacks and autoimmune conditions. \nImmunity is a hallmark of the immune system. Recovery from an invader renders the individual immune to a subsequent attack. The underlying mechanism involves memory T cells and memory B cells. These memory cells multiply rapidly when they reencounter the stimulating antigen. \nAllergies An allergic response involves both cellular and humoral mechanisms. In contrast, other types of sensitivities to foods, such as lactose intolerance or sulfite sensitivity, do not employ the immune system. Allergic responses can be generally classified as immediate or delayed hypersensitivities. Immediate hypersensitivity represents a rapid over-reaction of the immune system, often within minutes after exposure to the problem antigen. Particularly mast cells release histamine, leukotrienes and other stimuli that evoke swelling, hives, itchiness, copious mucus secretion and muscle spasm of the GI tract and bronchioles. The reaction is mediated by IgE antibodies. Anaphylactic shock results from an immediate hypersensitive allergic reaction affecting the whole body. Depending on how food allergy is defined, estimates of the prevalence range from 2% to 25% of the US population. Immediate allergic reactions account for only a small fraction of food allergies. Typical food allergies frequently involve IgG antibodies, and symptoms develop within hours or days after contact with a problematic food. Faulty digestion and increased gut permeability are often a root cause of multiple food allergies, because food allergens that are normally excluded, cross the intestinal barrier and enter the bloodstream. The resulting immune complexes, if not cleared rapidly, can lodge in various organs and tissues where they can trigger inflammatory conditions. Food allergies have been linked to a range of auto immune conditions, rheumatoid arthritis, for example.1 \nDetecting food allergies can be perplexing. The delay between ingesting a specific food and the development of sometimes vague symptoms often masks food allergy reactions. The most frequent symptom is fatigue. Other symptoms include delayed hypersensitivity, irritability, achy joints, blood sugar dysregulation, PMS-like symptoms, puffy eyes with dark circles and postnasal drip. Food allergies can cause asthma when they affect the respiratory tract; headache and insomnia when they affect the nervous system; and indigestion, irritable colon, \nconstipation or diarrhea when they affect the GI tract. A variety of laboratory tests to detect IgE and IgG subclasses responsive to particular antigens have been developed. These have varying degrees of reliability. \nBotanical Support of the Immune System A variety of botanical preparations have been reported as useful nutritional adjuncts for protocols designed to help normalize immune processes: \nJuglans nigra . Originating in Asia, Juglans nigra has a history of use in Greek and Roman traditions. It is said to be bitter, pungent, warm with cooling potential and is used with intestinal Qi stagnation.2 Black walnut leaf supports the immune system and normal tissue repair processes. \nOlea europaea . Buds and leaves of olive trees contain oleuropein, a phenolic glycoside, and rutin, luteolin and hesperidin - flavonoid glycosides.3 The latter flavonoids possess well-defined antioxidant properties and affect aspects of the vascular system as well as the immune system. Oleuropein is the bitter principle of green olives. It can effectively prevent the oxidation of LDL in vitro4. Antimicrobial properties of oleuropein have been reported, perhaps explaining the resistance of olive tree to microbial overgrowth.5 \nHydrangea arborescens . Contains thunberginols and hydrangenols which have been extensively studied by Japanese investigators. This family of compounds was shown to inhibit the release of histamine from rat mast cells and histamine-induced contraction of isolated guinea pig trachea.6 \nTHESE STATEMENTS HAVE NOT BEEN EVALUATED BY THE FOOD AND DRUG ADMINISTRATION. THIS PRODUCT IS NOT INTENDED TO DIAGNOSE, TREAT, CURE, OR PREVENT ANY DISEASE. \nPRODUCT INFORMATION Histoplex ® is available in bottles of 90 capsules. \nProduct Adjuncts: Bio-Immunozyme Forte TM , IPS ® . \nThunberginol A administered to rats and mice normalized various aspects of immune function.7 \nHesperidin . The rutinoside of hesperitin. Hesperidin is the predominant flavonoid in lemons and sweet oranges. In orange, lemon, and grapefruit skins, hesperidin and hesperitin are mainly responsible for the antioxidant activity of methanolic extracts.8 It seems also to have a membrane- stabilizing effect.9 Effects in supporting the immune system have been reported.10 \nAndrographis paniculata \n(Kalmegh). Folk traditions in India use this herb to support functions of the gastrointestinal tract, reduce flatulence, improve appetite and normalize liver function. Pretreatment of rats with extracts of this plant prevented carbon tetrachloride induced liver damage.11 Leaf extracts and isolated andrographolide inhibited lipid peroxidation due to exposure to carbon tetrachloride.12 \nCoriolus versicolor . Polysaccharide extracts of this mushroom are composed mainly of beta 1,4 glucan, together with some protein. This material has been in use in Japan, where it has been reported to enhance normal functioning of the immune system. For example, it improved T cell response in gut associated lymphoid tissue in mice.13 In rats, this extract increased B cells. The production of T cells increased in spleen and Peyer’s patches, but not thymus.14 These mushroom polysaccharide extracts are associated with superoxide dismutase activity.15 \nPicrorrhiza kurroa . Roots and rhizomes contain a mixture of flavonoids, including glycosides, piroside and kutkoside, picrorhizin, and the phenolic ether, apocynin. Apocynin was shown to inhibit the neutrophil oxidative burst in vitro.16 Apocynin inhibited the formation of thromboxane A2, while stimulating the release of prostaglandins by isolated guinea pig pulmonary macrophages.17 Picrorrhiza abstracts were found to support normal of T and B cell function using rodent model systems.18 \nLigsuticum porteri . The Ligsuticum family contains a number of compounds with aromatic character. Osha has long been used in folk traditions in Southwestern United States and Northern and Central Mexico.19, 20 \nOther Nutritional Support Dimethylglycine . Methyl donor. When lymphocytes were isolated from rabbits fed dimethylglycine and inoculated with viral or \nbacterial vaccines, they revealed higher proliferation rates than obtained from control animals. In addition, lymphocytes from immunized animals fed dimethylglycine showed an increased rate of DNA synthesis than controls.21 \nCalcium borogluconate . Boron has a role in calcium and magnesium metabolism, and possibly vitamin D.22 Boronate - containing polymer stimulated T cells in vitro.23 \nReferences \n1. Kjeldsen-Kragh J et al. Controlled trial of fasting and one year vegetarian diet in rheumatoid arthritis. Lancet 1991; 338: 899- 902. \n2. Holmes, Peter. The Energetics of Western Herbs. Vol. I, Artemis press, 1989; pp 415-417. \n3. Ficcara P et al. HPLC analysis of oleuropein and some flavonoids in leaf and bud of Olea Eurpoaea L. II Farmaco 1991; 46:803-815. \n4. Visioli R, Galli C. Oleuropein protects low density lipoprotein from oxidation. Life Sciences 1994; 55: 1965-1971. \n5. Tassou CC, Nychas CJL. Inhibition of Staphylococcus aureus by olive phenolics in broth and in a model food system. J Food Protection 1994; 57: 120-124, 132. \n6. Yamahara J, Murakami N. Development of bioactive func- tions in hydrangea ducki folium V. On the antiallergenic and antimicrobial principles of hydrangea. Chem Pharam Bulletin 1996; 44: 1440-1447. \n7. Yamahara J et al. Effects of thunberginol A continued in Hydrangea dulcis forium on type I-IV allergies. Nippon Jajurigaku Zasshi 1995; 105: 365-379. \n8. Kroyer G. Uber dei antioxidative Akivitatat von Zitrusfurchschalen (The antioxidant activity of citrus fruit peels). Z Ernarhrungswiss 1986; 25: 63-69. \n9. Santus R et al. Daflon as a cellular antioxidant and a membrane-stabilizing agent in human fibroblasts irradiated by ultraviolet A radiation. Photodermatol hotoimmunol Photo Med 1991; 8: 200-205. \n10. Galati EM et al. Biological effects of hesperidin, a citrus flavonoid: anti-inflammatory and analgesic activity. Farmaco 1994; 40: 709-712. \n11. Handa SS and Sharma A. Evidence of hepatoprotective activity of Andrographis panurata needs due to the diterpene lactone and andrographolide. Research and Development of Indigenous Drugs PC Dandiy and SB Vohora, eds. Institute of History of Medicine and Medical Research, New Delhi, 1989; 147-152. \n12. Handa SS, Sharma A. Hepatoprotective activity of andrographolide against galactoseamine and paracetamol intoxication in rats. Indian J Med Res 1990; 92: 284-292. \n13. Harada M et al. Oral administration of PSK can improve impaired antitumor CO4+ t cell responses in gut-associated lymphoid tissue of pathogen-free mice. Int J Cancer, 1997; 70: 362-372. \n14. Nakasaki H et al. Effect of the proteoglycan (PCK) on lymphocyte subsets in normal rats. Tokai J Exp Clin Med, 1995; 20: 37-44. \n15. Lin F et al. Free radical scavenger activities of mushroom polysaccharide extracts. Life Sci 1997; 60: 763-771. \n16. Simons J et al. Metabolic activation of natural phenols into selective oxidative burst agonists by activated human neutrophils. ree Radio Biol Med 1990; 8: 251-258 \n17. Engels R et al. Effects of apocynin on arachidonic acid metabolism. FEBS Letters 1992; 305: 254-256. \n18. Sharma ML et al. Immunostimulatory activity of Picrorrhiza kurroa leaf extract. J Ethanopharmacol 1994; 41: 185-192. \n19. Appelt GD. Pharmacologic aspects of selected herbs employed in Hispanic folk medicine in the San Luis Valley of Colorado. Liqusticum porteri (osha) and Matricaria Chamomilla (Manzanilla). J Ethnopharmacol 1985; 13: 51-55. \n20. Lihares E, Bye RA Jr. A study of four medicinal plant complexes of Mexico and adjacent United States. J. Ethanopharmacol 1987; 19: 153-183. \n21. Reap EA, Lawson JW. Stimulation of the immune response by dimethylglycine, a nontoxic metabolite. J Lab Clin Med 1990; 115: 481-486. \n22. Meacham SL et al. Effect of boron supplementation on blood and urinary calcium, magnesium and phosphorus, and urinary boron in athletic and sedentary women. Am J Clin Nutr 1995; 61: 341-345. \n23. Miyazaki H et al. Boronate-containing polymer as a novel mitogen for lymphocytes. Biochem Biophys Res Commun 1993;195: 829-836.October 31, 1997. \nLIT-035 Rev. 7/08 Copyright © 2006/2008 \n Nutritional support for those with allergies \nProduct #6340 Technical Support \nThe Immune System The immune system normally discriminates between “self” and “non-self” foreign substances. Thus, it represents an elaborate, finely tuned defense system to destroy microorganisms, cancer cells, or other invasive materials. However, an imbalanced immune system can attack the body’s own tissues (auto-immune conditions) and lead to cumulative oxidative stress. \nThe immune system consists of two branches, cellular immunity and humoral immunity. The first depends upon the active participation of multiple cell types, including a variety of phagocytic cells, to engulf invaders. Lymphocytes include highly specialized T cells, which proliferate and differentiate in the thymus gland. In a typical scenario, macrophages process ingested antigens and display recognition fragments on their surfaces. T helper cells acting as generals, read these antigens and in turn stimulate the production of T killer cells via lymphokines such as IL-2 and gamma interferon. Mast cells are a type of T cell embedded in tissues to fight localized infection. When they contact foreign materials, mast cells destroy them. In the process, they release histamine and other agents that cause edema, increase blood vessel permeability and recruit neutrophils to the site of inflammation. \nHumoral immunity pertains to proteins of the blood and lymph. This aspect of the immune system relies on B cells which mature to plasma cells that secrete specific antibodies and complement proteins to fight infections. Complement also triggers localized inflammation. T helper cells regulate the production and maturation of B cells through lymphokines. T suppressor cells gear down the immune response and thus are critical in allergy attacks and autoimmune conditions. \nImmunity is a hallmark of the immune system. Recovery from an invader renders the individual immune to a subsequent attack. The underlying mechanism involves memory T cells and memory B cells. These memory cells multiply rapidly when they reencounter the stimulating antigen. \nAllergies An allergic response involves both cellular and humoral mechanisms. In contrast, other types of sensitivities to foods, such as lactose intolerance or sulfite sensitivity, do not employ the immune system. Allergic responses can be generally classified as immediate or delayed hypersensitivities. Immediate hypersensitivity represents a rapid over-reaction of the immune system, often within minutes after exposure to the problem antigen. Particularly mast cells release histamine, leukotrienes and other stimuli that evoke swelling, hives, itchiness, copious mucus secretion and muscle spasm of the GI tract and bronchioles. The reaction is mediated by IgE antibodies. Anaphylactic shock results from an immediate hypersensitive allergic reaction affecting the whole body. Depending on how food allergy is defined, estimates of the prevalence range from 2% to 25% of the US population. Immediate allergic reactions account for only a small fraction of food allergies. Typical food allergies frequently involve IgG antibodies, and symptoms develop within hours or days after contact with a problematic food. Faulty digestion and increased gut permeability are often a root cause of multiple food allergies, because food allergens that are normally excluded, cross the intestinal barrier and enter the bloodstream. The resulting immune complexes, if not cleared rapidly, can lodge in various organs and tissues where they can trigger inflammatory conditions. Food allergies have been linked to a range of auto immune conditions, rheumatoid arthritis, for example.1 \nDetecting food allergies can be perplexing. The delay between ingesting a specific food and the development of sometimes vague symptoms often masks food allergy reactions. The most frequent symptom is fatigue. Other symptoms include delayed hypersensitivity, irritability, achy joints, blood sugar dysregulation, PMS-like symptoms, puffy eyes with dark circles and postnasal drip. Food allergies can cause asthma when they affect the respiratory tract; headache and insomnia when they affect the nervous system; and indigestion, irritable colon, \nconstipation or diarrhea when they affect the GI tract. A variety of laboratory tests to detect IgE and IgG subclasses responsive to particular antigens have been developed. These have varying degrees of reliability. \nBotanical Support of the Immune System A variety of botanical preparations have been reported as useful nutritional adjuncts for protocols designed to help normalize immune processes: \nJuglans nigra . Originating in Asia, Juglans nigra has a history of use in Greek and Roman traditions. It is said to be bitter, pungent, warm with cooling potential and is used with intestinal Qi stagnation.2 Black walnut leaf supports the immune system and normal tissue repair processes. \nOlea europaea . Buds and leaves of olive trees contain oleuropein, a phenolic glycoside, and rutin, luteolin and hesperidin - flavonoid glycosides.3 The latter flavonoids possess well-defined antioxidant properties and affect aspects of the vascular system as well as the immune system. Oleuropein is the bitter principle of green olives. It can effectively prevent the oxidation of LDL in vitro4. Antimicrobial properties of oleuropein have been reported, perhaps explaining the resistance of olive tree to microbial overgrowth.5 \nHydrangea arborescens . Contains thunberginols and hydrangenols which have been extensively studied by Japanese investigators. This family of compounds was shown to inhibit the release of histamine from rat mast cells and histamine-induced contraction of isolated guinea pig trachea.6 \nTHESE STATEMENTS HAVE NOT BEEN EVALUATED BY THE FOOD AND DRUG ADMINISTRATION. THIS PRODUCT IS NOT INTENDED TO DIAGNOSE, TREAT, CURE, OR PREVENT ANY DISEASE. \nPRODUCT INFORMATION Histoplex ® is available in bottles of 90 capsules. \nProduct Adjuncts: Bio-Immunozyme Forte TM , IPS ® . \nThunberginol A administered to rats and mice normalized various aspects of immune function.7 \nHesperidin . The rutinoside of hesperitin. Hesperidin is the predominant flavonoid in lemons and sweet oranges. In orange, lemon, and grapefruit skins, hesperidin and hesperitin are mainly responsible for the antioxidant activity of methanolic extracts.8 It seems also to have a membrane- stabilizing effect.9 Effects in supporting the immune system have been reported.10 \nAndrographis paniculata \n(Kalmegh). Folk traditions in India use this herb to support functions of the gastrointestinal tract, reduce flatulence, improve appetite and normalize liver function. Pretreatment of rats with extracts of this plant prevented carbon tetrachloride induced liver damage.11 Leaf extracts and isolated andrographolide inhibited lipid peroxidation due to exposure to carbon tetrachloride.12 \nCoriolus versicolor . Polysaccharide extracts of this mushroom are composed mainly of beta 1,4 glucan, together with some protein. This material has been in use in Japan, where it has been reported to enhance normal functioning of the immune system. For example, it improved T cell response in gut associated lymphoid tissue in mice.13 In rats, this extract increased B cells. The production of T cells increased in spleen and Peyer’s patches, but not thymus.14 These mushroom polysaccharide extracts are associated with superoxide dismutase activity.15 \nPicrorrhiza kurroa . Roots and rhizomes contain a mixture of flavonoids, including glycosides, piroside and kutkoside, picrorhizin, and the phenolic ether, apocynin. Apocynin was shown to inhibit the neutrophil oxidative burst in vitro.16 Apocynin inhibited the formation of thromboxane A2, while stimulating the release of prostaglandins by isolated guinea pig pulmonary macrophages.17 Picrorrhiza abstracts were found to support normal of T and B cell function using rodent model systems.18 \nLigsuticum porteri . The Ligsuticum family contains a number of compounds with aromatic character. Osha has long been used in folk traditions in Southwestern United States and Northern and Central Mexico.19, 20 \nOther Nutritional Support Dimethylglycine . Methyl donor. When lymphocytes were isolated from rabbits fed dimethylglycine and inoculated with viral or \nbacterial vaccines, they revealed higher proliferation rates than obtained from control animals. In addition, lymphocytes from immunized animals fed dimethylglycine showed an increased rate of DNA synthesis than controls.21 \nCalcium borogluconate . Boron has a role in calcium and magnesium metabolism, and possibly vitamin D.22 Boronate - containing polymer stimulated T cells in vitro.23 \nReferences \n1. Kjeldsen-Kragh J et al. Controlled trial of fasting and one year vegetarian diet in rheumatoid arthritis. Lancet 1991; 338: 899- 902. \n2. Holmes, Peter. The Energetics of Western Herbs. Vol. I, Artemis press, 1989; pp 415-417. \n3. Ficcara P et al. HPLC analysis of oleuropein and some flavonoids in leaf and bud of Olea Eurpoaea L. II Farmaco 1991; 46:803-815. \n4. Visioli R, Galli C. Oleuropein protects low density lipoprotein from oxidation. Life Sciences 1994; 55: 1965-1971. \n5. Tassou CC, Nychas CJL. Inhibition of Staphylococcus aureus by olive phenolics in broth and in a model food system. J Food Protection 1994; 57: 120-124, 132. \n6. Yamahara J, Murakami N. Development of bioactive func- tions in hydrangea ducki folium V. On the antiallergenic and antimicrobial principles of hydrangea. Chem Pharam Bulletin 1996; 44: 1440-1447. \n7. Yamahara J et al. Effects of thunberginol A continued in Hydrangea dulcis forium on type I-IV allergies. Nippon Jajurigaku Zasshi 1995; 105: 365-379. \n8. Kroyer G. Uber dei antioxidative Akivitatat von Zitrusfurchschalen (The antioxidant activity of citrus fruit peels). Z Ernarhrungswiss 1986; 25: 63-69. \n9. Santus R et al. Daflon as a cellular antioxidant and a membrane-stabilizing agent in human fibroblasts irradiated by ultraviolet A radiation. Photodermatol hotoimmunol Photo Med 1991; 8: 200-205. \n10. Galati EM et al. Biological effects of hesperidin, a citrus flavonoid: anti-inflammatory and analgesic activity. Farmaco 1994; 40: 709-712. \n11. Handa SS and Sharma A. Evidence of hepatoprotective activity of Andrographis panurata needs due to the diterpene lactone and andrographolide. Research and Development of Indigenous Drugs PC Dandiy and SB Vohora, eds. Institute of History of Medicine and Medical Research, New Delhi, 1989; 147-152. \n12. Handa SS, Sharma A. Hepatoprotective activity of andrographolide against galactoseamine and paracetamol intoxication in rats. Indian J Med Res 1990; 92: 284-292. \n13. Harada M et al. Oral administration of PSK can improve impaired antitumor CO4+ t cell responses in gut-associated lymphoid tissue of pathogen-free mice. Int J Cancer, 1997; 70: 362-372. \n14. Nakasaki H et al. Effect of the proteoglycan (PCK) on lymphocyte subsets in normal rats. Tokai J Exp Clin Med, 1995; 20: 37-44. \n15. Lin F et al. Free radical scavenger activities of mushroom polysaccharide extracts. Life Sci 1997; 60: 763-771. \n16. Simons J et al. Metabolic activation of natural phenols into selective oxidative burst agonists by activated human neutrophils. ree Radio Biol Med 1990; 8: 251-258 \n17. Engels R et al. Effects of apocynin on arachidonic acid metabolism. FEBS Letters 1992; 305: 254-256. \n18. Sharma ML et al. Immunostimulatory activity of Picrorrhiza kurroa leaf extract. J Ethanopharmacol 1994; 41: 185-192. \n19. Appelt GD. Pharmacologic aspects of selected herbs employed in Hispanic folk medicine in the San Luis Valley of Colorado. Liqusticum porteri (osha) and Matricaria Chamomilla (Manzanilla). J Ethnopharmacol 1985; 13: 51-55. \n20. Lihares E, Bye RA Jr. A study of four medicinal plant complexes of Mexico and adjacent United States. J. Ethanopharmacol 1987; 19: 153-183. \n21. Reap EA, Lawson JW. Stimulation of the immune response by dimethylglycine, a nontoxic metabolite. J Lab Clin Med 1990; 115: 481-486. \n22. Meacham SL et al. Effect of boron supplementation on blood and urinary calcium, magnesium and phosphorus, and urinary boron in athletic and sedentary women. Am J Clin Nutr 1995; 61: 341-345. \n23. Miyazaki H et al. Boronate-containing polymer as a novel mitogen for lymphocytes. Biochem Biophys Res Commun 1993;195: 829-836.October 31, 1997. \nLIT-035 Rev. 7/08 Copyright © 2006/2008 \n .
