Phosphatidylcholine (Neurological & Detoxification Support) 100 Softgels
Phosphatidylcholine by Biotics Research Corp.
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Phosphatidylcholine is Support for Healthy Membrane & Liver Function
Supplemental source of this important phospholipid, which is a major constituent of cell membranes, and is important for normal cellular membrane function and repair.
Phosphatidylcholine is gluten and dairy free!
Dietary choline, an essential cellular nutrient, is ingested in the diet primarily in the form of phosphatidylcholine. Phosphatidylcholine is the principal circulating phospholipid in plasma, where it is an integral component of the lipoproteins, espe- cially HDL. It plays an important role in both the structure and function of mammalian organ membranes,1, 2 and is the prime phospholipid in the mammalian heart, accounting for 40% of the total membrane phospholipids.3 It is estimated that great- er than 98% of the blood and tissue choline is sequestered in Phosphatidylcholine.
Phosphatidylcholine, a glycerophospholipid, is the key building block of membrane bilayers, and makes up a very high proportion of the outer leaflet of the plasma membrane. Following ingestion, most of the Phosphatidylcholine is broken down and subsequently incorporated into cellular membranes.
Phosphatidylcholine serves as an excellent source of methyl groups for various chemical reactions, as it can supply up to three methyl groups per molecule, thus plays an important role in metabolic regulation. Additionally, it is present in a variety of molecular species in human tissues, primarily due to the variability of the fatty acid tails.
Choline plays a fundamental role in the synthesis of membrane phospholipid components of the cell membrane. Although choline may be synthesized in vitro, from either methionine or serine, it is considered an essential nutrient.4 The composition of essential fatty acids in phosphatidylcholine determines its value in promoting health.
Lowered blood choline is frequently displayed as liver steatosis (fatty liver) and related dysfunctions, and a deficiency in choline has been correlated with deleterious affects on the expression of a variety of genes, including those involved in cell proliferation, cell differentiation and apoptosis.
Choline deficiency has also been associated with liver dysfunction and neoplastic diseases, as well as with neurodegenerative disorders, including Alzheimer’s and Parkinson’s disease. 5 A source of choline contributes to the biosynthesis of the neurotransmitter acetylcholine, a neurotransmitter which has many functions in the body, including its involvement in muscle control and memory.
Phosphatidylcholine has been implicated as the preferred source of choline for this action. 6 Hepatic phosphatidylcholine is considered an important component in liver function as well as in metabolic regulation.7 A decrease in hepatic phosphatidylcholine has been associated with an accumulation of triglycerides in the liver, along with a reduced level of plasma lipids and plasma lipoprotein. 8 In animal studies choline intake was correlated to a hepatoprotective effect. Consequently phosphatidylcholine supplementation in persons with liver impediments is particularly important.
Biotics Research Corporation’s Phosphatidylcholine is supplied as a highly bioavailable form, which is well tolerated, odor free, readily absorbed and most importantly tested to ensure quality and purity.
RECOMMENDATION: One (1) softgel capsule one (1) to three (3) times each day as a dietary supplement or as otherwise directed by a healthcare professional.
References: 1. White DA. Form and Function of Phospholipids. Eds. Ansell GB, Hawthorne JN, Dawson RMC. Elsevier, Amsterdam. 1973 pp. 441-482. 2. Coleman, R. Biochim. Biophys. Acta 1973 300;1-30. 3. Ansell GG, Spanner S. Phospholipids. Eds. Hawthorne JN, Ansell GB. Elsevier. Amsterdam 1982 pp. 1-49. 4. Blusztajn JK. Developmental neuroscience: enhanced choline, a vital amine. Science 1998 281:794-795. 5. Michel v, Yuan Z, Ramsubir S, Bakovic M. Choline Transport for Phospholipid synthesis. Exp Biol Med 2006 231:490-504. 6. Werbach MR, Moss J. Textbook of Nutritional Medicine. 1999 Third Line Press, Inc. 7. Chang HM, Mai FD, Chen BJ, Wu UI, Huang YL, Lan CT, Ling YC. Sleep deprivation redisposes liver to oxidative stress and phospholipid damage: a quantitative molecular imaging study. J Anat. 2008 Mar;212(3):295-305. Epub 2008 Jan 25. 8. Jacobs RL, Devlin C, Tabas I, Vance DE. Targeted deletion of hepatic TP:phosphocholine cytidylyltransferase alpha in mice decreases plasma high density and very low density lipoproteins. J Biol Chem. 2004 Nov 5;279(45):47402-10.